Challenge Dream+ Tangential Flow Filtration(TFF) System

The single-use, fully automated tangential flow filtration (TFF) system is built with GMP-compliant fluid contact materials and delivers efficient, flexible filtration solutions to meet production needs from clinical development to commercial manufacturing. It offers intuitive operation and seamless scalability across different process scales, helping users significantly reduce production time and costs. The system is widely applied in the manufacturing of monoclonal antibodies, ADCs, gene therapies, viral products, mRNA vaccines, and plasmid DNA, supporting processes such as concentration, purification, and continuous buffer exchange.

Product Detail

Features

Single-use design concept easily addresses the challenges of cleaning validation;
High level of automation from automatic feed to online integrity testing, the entire TFF process is fully automated, minimizing risks from manual intervention and achieving truly intelligent tangential flow operation;
Supports PUPSIT (Pre-Use Post-Sterilization Integrity Testing), compliant with MEA and other relevant regulatory requirements;
Compact tubing layout ensures minimal hold-up volume;
Flexible membrane compatibility ,supports both cassette membranes and hollow fibers;
Adaptable to different setups, flexibly integrate with various single-use bags or tanks based on user requirements；
Compliant with FDA 21 CFR Part 11 , complete validation documentation is provided.

Challenge Filair® PTFE Hydrophobic Sterile Filter with High Retention and High Throughput